Dark Canyon Labs is excited to announce publication of positive Phase 2 results in Clinical and Translational Gastroenterology. View the entire article here.
Study Highlights
What is known:
The gold standard for colonoscopy prep safety and efficacy is 4L polyethylene glycol-electrolyte solution (PEG-ELS).
40% of patients have known risk factors for a suboptimal prep, and 4L PEG-ELS is recommended for this population.
The tolerability of 4L PEG-ELS is limited by its taste and volume.
What is new here:
DCL-101 is a novel pill-based colonoscopy prep that is taste-free and compositionally identical to 4L PEG-ELS. Safety and efficacy of DCL-101 appear to be similar to 4L PEG-ELS.
DCL-101 is significantly better tolerated than 4L PEG-ELS. 87% of patients found DCL-101 to have “no taste” or “good taste.” The vast majority of patients found DCL-101 “easy to take,” and experienced far less dread during the prep.
Palatability has a large impact on overall colon prep tolerability.